Research

Investigator Initiated Studies

Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders (CALM)
ClinicalTrials.gov ID NCT06081348
Sponsor Holland Bloorview Kids Rehabilitation Hospital

Ontario Locations
McMaster University | Hamilton, Ontario, Canada, L8S4K1
Queen’s University | Kingston, Ontario, Canada, K7M8A6
University of Western Ontario, Lawson Health Research Institute | London, Ontario, Canada, N6A 5W9
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M4G 1R8

Fluoxetine in KCNC1-related Disorder
ClinicalTrials.gov ID NCT06341127
Sponsor Holland Bloorview Kids Rehabilitation Hospital

Ontario Locations
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M5G1R8

A Pilot Study of Riluzole Versus Placebo in the Treatment of Children and Adolescents With ASD (RILISE)
ClinicalTrials.gov ID NCT01661855
Sponsor Holland Bloorview Kids Rehabilitation Hospital

Ontario Locations
Offord Centre for Child Studies | Hamilton, Ontario, Canada, L8S 4K1
Lawson Health Research Institute | London, Ontario, Canada, N6A 5W9
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M4G 1R8

Tideglusib vs. Placebo in the Treatment of Adolescents With Autism Spectrum Disorders (TIDE)
ClinicalTrials.gov ID NCT02586935
Sponsor Holland Bloorview Kids Rehabilitation Hospital

Ontario Locations
McMaster University, Offord Centre for Child Studies | Hamilton, Ontario, Canada, L8S 4K1
University of Western Ontario, Lawson Health Research Institute | London, Ontario, Canada, N6A 5W9
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M4G 1R8

Arbaclofen vs. Placebo in the Treatment of Children and Adolescents With ASD (ARBA)
ClinicalTrials.gov ID NCT03887676
Sponsor Holland Bloorview Kids Rehabilitation Hospital

Ontario Locations
McMaster University, Offord Centre for Child Studies | Hamilton, Ontario, Canada, L8S 4K1
Queen’s University | Kingston, Ontario, Canada, K7M 8A6
University of Western Ontario, Lawson Health Research Institute | London, Ontario, Canada, N6A 5W9
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M4G 1R8

Industry Sponsored Initiated Studies 

NAVEX2-73 Study in Pediatric Patients With Rett Syndrome (EXCELLENCE)
ClinicalTrials.gov ID NCT04304482
Sponsor Anavex Life Sciences Corp.

Alberta Locations
Alberta Children’s Hospital | Calgary, Alberta, Canada, T3B 6A8
British Columbia Locations
British Columbia Children’s Hospital | Vancouver, British Columbia, Canada, V6H 3V4
Ontario Locations
Children’s Hospital LHSC | London, Ontario, Canada, N6A 5W9
Holland Bloorview Kids Hospital | Toronto, Ontario, Canada, M5H 3W4

A 12-Week Placebo-Controlled Study to Investigate the Efficacy, Safety, and Tolerability of RO7017773 in Participants Aged 15-45 Years With Autism Spectrum Disorder (ASD)
ClinicalTrials.gov ID NCT04299464
Sponsor Hoffmann-La Roche

British Columbia Locations
Okanagan Clinical Trials | Kelowna, British Columbia, Canada, V1Y 1Z9
Newfoundland and Labrador Locations
Janeway Childrens Health | St. John’s, Newfoundland and Labrador, Canada, A1B 3V6
Ontario Locations
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M4G 1R8
London Health Sciences Centre | London, Ontario, Canada, N6A 4G5

ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)
ClinicalTrials.gov ID NCT05081245
Sponsor MapLight Therapeutics

British Columbia Locations
OCT Research ULC (dba Okanagan Clinical Trials) | Kelowna, British Columbia, Canada, V1Y 1Z9
Ontario Locations
Lawson Health Research Institute/London Health Sciences Centre | London, Ontario, Canada, N6A 5W9
Holland Bloorview Kids Rehabilitation Hospital | Toronto, Ontario, Canada, M4G 1R8